Innovative Research News and Updates

Diabetic Peripheral Neuropathy Study


Are you 70 years of age or older and take long acting insulin (NPH, levemir, or Lantus)?


Study for Diabetic Kidney Disease


Study for Knee Pain


Study for Cold Sores


Proposed Mylan asthma ad


Update October 27, 2014


Should older adults drink milk?

Coffee, tea or juice is most often an adult's beverage of choice in the morning. But it would be wise to include some milk.

Since older adults are prone to loss of bone mass as they age, fortifying their diet with calcium-rich foods is important. Calcium also contributes to the proper functioning of the heart, muscles, and nerves and helps the blood to clot.

While other foods can be sources of calcium, dairy is the best source. Adding a cup of milk to that bowl of breakfast cereal meets almost one-third of the daily recommended amount of calcium. A 6-ounce carton of yogurt contains 25% of the daily total.

The National Institutes of Health says that adults require 1,000 mg of calcium daily and 1,200 mg after age 70. One 8-oz. glass of milk provides 300 mg of calcium. Milk is also fortified with vitamin D, which helps the body absorb calcium.

Some older adults find that the lactose in milk becomes difficult to digest, resulting in bloating, pain, diarrhea or socially-embarrassing gas. Fortunately, many lactose-free foods are now available—everything from milk in the dairy section to ice cream in the freezer case.

For more information, see:

Update September 30, 2014

It's a Morning World


Exposure to morning light seems to make it easier to lose weight, according to several studies. The shorter wave lengths of blue light prevalent in the early morning has been shown to have the strongest effect on the circadian system, or internal body clock. These rhythms of our lives control even the way we metabolize fat.

There is growing evidence that light plays a role in regulating body weight. Researchers at Northwestern University report: "Light exposure can influence sleep and circadian timing, both of which have been shown to influence weight regulation."

one study, for example, examined the effect upon mass body index (BMI) of limiting sleep and augmenting exposure to light. The subjects' metabolism increased and appetite decreased, even when sleep was restricted to five hours a night. (Not that such deprivation is recommended!) In another study, obese women who were exposed to light (in addition to exercise) reduced their body fat more than women in the control group who only exercised.

Wonder how this light exposure works? Our biological clock is affected by environmental cues. The timing of daylight influences the secretion of hormones, such as melatonin and cortisol, as well as appetite-regulating hormones. When our eyes signal the brain that it is getting dark, melatonin begins to rise and stays elevated throughout the night as we sleep. In early morning, the hormone cortisol naturally increases when our eyes signal daylight.

But there can be a dark side to cortisol. It is nicknamed the "stress" hormone and can be released at inappropriate times. In fact, it can be the culprit behind such physical problems as cardiovascular disease and obesity. When excess cortisol is secreted, we may gain weight...and not only because stress plays havoc with healthy eating patterns. Unfortunately, stress weight gain seems to go to the abdomen, rather than the hips. That is serious, because depositing weight on the abdominal area correlates with risk of cardiovascular disease.

So try spending as much as 45 minutes in the early morning light, when possible. Whether walking through a parking area or sitting on a sunny deck, it enhances your day to go outside.


Update August 26, 2014

Memorization Trains Brains

The brain is a learning tool, not a passive sponge, so learning takes active effort. Lots of useful facts need to be memorized for quick recall. It isn't practical to look up everything on the Internet.

Now that school has started, students are busy learning facts about math, social studies and maybe even memorizing famous gems spoken by patriots of the past. Recent studies have shown that memorization of facts, speeches or poetry provide important benefits to students' brain function and development and serve as the basis for higher level learning.1

It takes repetition for facts to "stick" in our short term memory. Once that knowledge is acquired, then we can evaluate and make new connections at a so-called higher level of thinking.

Some learning theorists have dispelled the value of repetition and rote memorization. But no such aversion to practice and drill exists in school athletics, where a "gym rat" will attempt daily to make 100 baskets from the free throw line. Students of the martial arts develop their muscle memory by repeating forms or moves until they are automatic. Serious musicians spend hours mastering their instrument and continue to practice for the rest of their lives.

"Before students can think critically," says Ben Johnson of Johnson Education Group, "they need to have something to think about in their brains. It is true that knowledge without comprehension is of little use, but comprehension requires knowledge and it takes time and effort to acquire."

Learning actually changes the structure and function of the brain, according to Donna Wilson and Marcus Conyers of Nova Southeastern University. If students realize that intelligence is expandable, they may be more persistent in training their brains...starting with memorizing the basics of math and maybe a little poetry too.

Here's an aside related to last month's news blog:
Studies show that much of the memory consolidation process takes place during sleep. Children who struggle to remember what they have learned need to get plenty of sleep—10 hours a night.

For further discussion about how the brain learns, check out these sites:

1 Kris Freeland of Learning Services for Idaho Public Television, re last spring's challenge to memorize the Gettysburg Address.

Update July 30, 2014

Did you get your 7.2 hours of sleep last night?

 How long you should sleep each night? Be watching 6 months from now for updated recommendations. Panels of sleep researchers are almost ready to announce the findings from many sleep studies: Adults don't necessarily need the standard 8 hours of sleep a night.

In fact, some studies show a connection between getting 7 hours, 13 minutes of sleep and performing at your peak. (Timothy Morgenthaler, president of the American Academy of Sleep Medicine, cautions that sleep and performance are associated factors, but one doesn't scientifically prove the other.) Other studies also indicate that people are healthier with about 7 hours of sleep.

 Here's the caveat: Getting too little sleep can slow down your mental performance and decrease your ability to pay attention—whether driving, working at your computer, sitting in class or attending a meeting. Habitually sleeping just 20 or 30 minutes less than a minimum of 7 hours can affect how fast you think or react, according to David Dinges, University of Pennsylvania. Some say sleep deprivation may cause memory loss and weight gain.

Individuals differ. So evaluate what works for you. How do you feel after sleeping 7 hours or less? 8 hours or more?

Since school is resuming soon, families should plan their children's sleep schedules carefully. School-age children need 10 hours a night, and growing teenagers require almost as much sleep—9 to 10 hours.

For more opinions about the optimal night's sleep, see this article by Sumathi Reddy:

Update June 26, 2014

Drink plenty of water and take it easy on your heart

Do you have citrus slices floating in a tall pitcher of water in your refrigerator? Keeping an attractive drink like that so close at hand may encourage you to drink more fluids. Adequate hydration is critical in Florida in the summer time, so also carry a water bottle with you whenever you leave home.

Prevention is the key: The Cleveland Clinic recommends that you drink water before you get thirsty. If you wait until you feel thirsty, you are probably already dehydrated.

 Why do our bodies need so much water, especially in the summer time? When we are active, our muscles create heat. To keep our internal temperature from rising, sweat glands attempt to cool the tissues under our skin through evaporation. But this process feels less efficient in a humid climate, compared to the relief which evaporation provides in a dry, breezy climate. Nevertheless, the loss of fluids is significant and can be dangerous to your heart. If you are dehydrated, your heart must strain to pump blood to your muscles. Early symptoms may include circulatory issues, such as flushing, headache, and swollen feet.

 The American College of Sports Medicine makes these recommendations for hydrating your body for outdoor summer activity:

Before: 16-20 oz. of fluid, 1-2 hours in advance
During: 6-12 oz. of fluid every 15 minutes
After: 16-24 oz. of fluid
Check the color of your urine: It should be clear, pale or straw-colored. If it's darker, drink some more.

 Share your knowledge about hydration with your summer guests as they launch out to tour theme parks or hit the beach. And serve them a slice of juicy watermelon when they return.

Update May 22, 2014

Thinking hard at work...or letting your mind wander

 Some of the most interesting research of this century deals with how the human brain works! Thanks to the technology of sophisticated machines, neuroimaging can reveal what is happening inside the brain.

Here are two intriguing discoveries which may affect you at work:

Deadlines motivate us with more urgency to get going, using the brain's "task positive" network. But at the same time, the stress created by tight deadlines impedes another part of the brain that might offer new and creative solutions to problems.

Dr. Richard Boyatzis from Case Western Reserve University quips, "The very moments when in organizations we want people to think outside the box, they can't even see the box."

 Sometimes people do their best thinking away from work. That doesn't mean you should head to the beach instead returning to the office after lunch! But letting the mind wander opens the way for the creative part of your brain to become active.

"When people hit a wall in their thinking, in general they start thinking harder," says Harvard Med School's assistant clinical professor, Srini Pillay. "What the neuroscience research tells us is that it's more important to think differently."

Read more about applying brain research to your working life in this article from the Wall Street Journal:
The Inner Workings of the Executive Brain

Update April 17, 2014

Are you overdue for a Tetanus Booster Shot?

Childhood vaccinations for tetanus do not last forever.

How long has it been for you? Does it really matter?

Adults should get a booster every 10 years. Although we may not hear about tetanus or "lockjaw" very often, the opportunity to come into contact with the Clostridium bacteria lies all around us. These bacteria which cause tetanus live in soil, saliva, dust, and manure. A deep cut, puncture wound or burn can be just the chance for them to enter your body. And that could spell a medical emergency.

The infection from these bacteria causes a painful tightening of the muscles, usually all over the body. This can include a "locking" of the jaw, so that the patient cannot open his or her mouth or swallow. One in 10 tetanus patients will die.

What should you do if you step on a nail? Or get cut by a rusty piece of metal?

Cleanse the wound immediately and thoroughly. Then get a tetanus shot, if it has been more than a few years since your last booster.

Prevention is the best medicine. Tetanus vaccine is available at Premier Family Medicine, 727.584.8777.

For more information about tetanus, see

Update March 21, 2014

When Should You Replace Eye Makeup?

When lipstick turns sticky and difficult to apply, the answer is obvious: Toss it!
But a perfectly good tube of mascara...?

 Eyes are particularly vulnerable to germ-laden applicators and pencils.

Conjunctivitis, popularly known as pink eye, will strike an unattractive accent to any red-hued ensemble. It is extremely contagious to the rest of the family as well. Remember Bob Costas and his swollen eyes at the Winter Olympics?
Blepharitis, an inflammation of the eyelash follicles, can become chronic with recurring flare-ups. Adding hot washcloth soaks and antibiotic eyedrops to your makeup routine is not fun.

How does makeup become contaminated?

You may unknowingly spread germs back into the container. Airborne germs and bacteria are often rampant in the moist confines of our bathrooms. Replacing the applicator brush in the mascara or liquid eyeliner may introduce germs into the product itself.

Just to be safe, some experts suggest starting over with fresh eye products every three months. However, a pencil eyeliner can be cleaned easily with a tissue dampened in alcohol.

For more advice on keeping your makeup routine healthy, see comments from a New York City dermatologist, Dr. Gervaise Gerstner, in a column written by Elizabeth Holmes in the Wall Street Journal (Jan. 7. 2014). Makeup Without Germs

Update: March 3, 2014

What are good vitamins to take?

This question no longer has a simple answer. In the past, it has been accepted practice for people to take Vitamin C to minimize colds, and for those who don't get much sunshine to take some Vitamin D. Maybe they would add a multi-vitamin, just to cover all the bases.

Some recent and respected research shows that vitamin pills may have no more than a placebo effect. In other words, we feel better about skimping on the recommended portions of fruits and vegetables if we pop a vitamin pill. A vitamin pill not only soothes our conscience for making poor diet choices, it has the added advantage of being a whole lot easier than prowling the produce aisles and coming back to the kitchen to peel and prepare food.

Sifting through some expert opinions

Most vitamin supplement trials show no benefit for healthy people, according to Dr. P. Mulai Doraiswamy of Duke University. In fact, overdoses of Vitamin E can actually be harmful.

"The best source of vitamins is a plant-based diet," says Dr. Marisa C. Weiss of Lankenau Medical Center in Wynnewood, PA. She suggests eating fresh or frozen produce in "all colors of the rainbow."

However, she does recommend supplementing some Vitamin D for the many women who are deficient. Why do many women lack vitamin D? Because they tend to be indoors most of the time, or they cover up with clothes or sunscreen when outside.

Update: January 16, 2014

Resolve: Eat just a little bit MORE...?

Did you already resolve to eat less during 2014? How's that resolution working for you?

Time management experts tell us that any major project can be broken down into smaller, more do-able parts. So you can try eating less by eating more...!

Begin small by adding to your diet a little more fiber and a few more healthy nutrients to help satisfy your appetite:

Add just one more serving of fruit or vegetables to your daily diet this week.

  • 8-10 baby cut carrots
  • 1 stalk celery
  • 1 cup green beans
  • 1 small apple or 1 cup applesauce
  • 1 small orange
  • ½ cup raisins
  • 8 strawberries

Sure, the official government guidelines recommend filling half your plate with fruits and vegetables. That amounts to 2 - 3 cups of vegetables and 1 ½ - 2 cups of fruit daily.

But even adding one more serving will be a good start!

Admittedly, fresh produce can be expensive when out-of-season and sometimes goes to waste. So don't discount frozen and canned foods. They are picked and processed at their peak and may have more nutrition than fresh produce that has been around for a while.

For lots more ideas and tempting pictures of fruits and vegetables, go to

Update: December 9, 2013

Holidays are approaching:  Are you lonely...or just alone?

The two words are not the same.  It's okay to be alone by choice...but it's no fun to feel lonely.

Actually, more Americans today really are alone.  One-person households comprised 27% of the population in 2012, according to the US Census Bureau, a jump from 17% in 1970.  But these people are not necessarily lonely.  Elizabeth Bernstein in the Wall Street Journal article Alone or Lonely:  It's All in How You Think About It points out that someone with a generally positive attitude can feel contented spending time alone—working around home, reading or watching TV, listening to music, enjoying a pet.

But unbidden memories may arise when a single person deliberates over putting up decorations or cooking something special.  That wistfulness for holiday traditions may induce loneliness.

At Innovative Research we approach wellness from its social and emotional aspects, as well as the physical.  Here are our suggestions for combating loneliness during the holiday season.

Cultivate your relationship with others.  Reconnect with acquaintances from the past—whether by phone or email or greeting card.  Plan a simple get-together with a friend you enjoy.  Invite someone to join you for coffee or a walk through downtown to see the lights.

Manage stress effectively.  Try not to obsess over gift-giving.  Give yourself permission to get more sleep.  Stop telling yourself how lonely you are.  Attend a group event—even if you arrive by yourself to join strangers at a sports venue, a movie or a holiday musical.  Take part in a religious service or celebration, where you can feel welcomed.

Practice a positive attitude.  Remember, you aren't the only one who is alone during the holidays.  Fight the urge to isolate yourself.  Rather than focusing on what you are missing, pursue new opportunities.  Make an effort to get out and be around people.  Take the initiative!

To read Ms. Bernstein's article, go to

Update: November 18, 2013

Abnormal gene causes childhood leukemia, if not paired with normal gene

A new study shows that an abnormal gene causes childhood leukemia, if not paired with a normal gene. The discovery opens up possibilities for new treatment strategies, thanks to recent research announced by the University of Washington at Seattle.

Dr. Marshall Horwitz, professor of pathology and of medicine at the University of Washington, is a co-author of the study released Sept. 8, 2013 in the journal Nature Genetics. Other researchers included those at St. Jude Children's Research Hospital in Memphis, Tenn., led by Dr. Charles Mullighan; at Memorial Sloan-Kettering Cancer Center in New York City led by Dr. Kenneth Offit, and others at UW.

"The abnormal gene, PAX5, has long been known to be involved in acute lymphoblastic leukemia. The new study indicates a mutation in the gene alone is sufficient to eventually cause the disease, which affects nearly 3,000 children and teenagers in the United States each year," according to a news release from UW Today.

This abnormal PAX5 gene does not cause leukemia as long as it is paired with a normal version of the PAX5 gene, said Dr. Horwitz, but if the normal copy of the gene is lost and the abnormal variant is unopposed, some white blood cells fail to function normally and, instead, turn into leukemia cells.

In the case of the families in the study, all the children who developed leukemia had damage to a chromosome in the affected blood cells. In the future, the discovery should make it possible to screen for the gene in families with a history of the disease and suggests new strategies for treatment.

Dr. Horwitz speculated that it may be possible to design treatments that induce leukemic cells to begin to behave like normal cells again. Such treatments might be more effective and have far fewer side effects than chemotherapy, the current standard treatment for these cancers, he explained.

Update: October 31, 2013

Happy Halloween from Innovative Research!

photo 1

Update: October 14, 2013

We are celebrating 2 new employees Paula (on the left) and Rose (on the right) who joined our team! Cake was made by Mary.

Paula and Rose Cake by Mary

Update: September 12, 2013

Congratulations to Mary celebrating her 7th anniversary with the company and Chris celebrating his 2nd anniversary!

Update: August 15, 2013

Radio AM 1340 is doing a blood drive for OUR TROOPS during Labor Day. We will be sponsoring with a radio announcement 9/2, 9/4, and 9/6. We wanted everyone to know and to listen to the beautiful message that will be broadcast. Our military sacrifices every day for our freedom, so those of us that cn donate blood, please try to do so. Thanks!

Update: August 7, 2013

Website Goes live

Dear all,

I wanted to inform everyone that our website has gone live! I hope you find this to be a valuable informational tool for your center. Also, please note there will be online search directives to be implemented shortly to enhance the search experience.

Local IRB sites please note that the website has only been approved for use for central sites thus far. All local sites have to have the website approved by their local IRB's. The website has Video testimonials and our study video. Website screen shots are available in Intralinks and also we will send you an email with these screen shots and the videos, along with video script in a follow up communication so that you can send them for Local IRB approval. Once all have been approved we will add your site to the Website so that potential subjects can contact you. So please make sure you inform Megan or Bryan once you have received approval.

Update: August 6, 2013

Innovative Research of West Fl., Inc. and Miguel Trevino, MD Participates in Phase III Trial of Investigational Vaccine for Prevention of Clostridium difficile (C. diff)

Volunteers Needed for Study of Vaccine to Prevent Leading Cause of Healthcare-Associated Infections

Clearwater, Fl. Miguel Trevino, MD–announced today that it is participating in a clinical study to evaluate the safety, immunogenicity and efficacy of an investigational vaccine for the prevention of primary symptomatic Clostridium difficile (C. diff) infection (CDI). C. diff is a potentially life-threatening, spore-forming bacterium that causes intestinal disease. While most types of healthcare-associated infections (HAIs) are declining, C. diff is emerging as a leading cause of life-threatening, HAIs worldwide. The infection poses the greatest danger for older adults in hospitals or long-term care facilities who take broad-spectrum antibiotics.[i]

Innovative Research of West Fl., Inc. joins more than 200 sites across 17 countries from around the world in the Cdiffense clinical trial, a Phase III randomized, observer-blind, placebo-controlled study. Volunteers for the study should be age 50 or older and planning an upcoming hospitalization of more than 72 hours for a surgical procedure. People in this age group who have had at least two hospital stays, each lasting more than 72 hours, and have received systemic antibiotics in the past year are also eligible.

"With the emergence of difficult-to-manage strains of C. diff, CDI has become more frequent, more severe and more difficult to treat in recent years, raising concerns about how to control it and prevent transmission," explained Miguel Trevino, MD of Innovative Research of West Fl., Inc. "Vaccination could be an efficacious, cost-effective and important public-health measure to protect individuals from C. diff."

In 2010, the U.S. Food and Drug Administration (FDA) granted fast-track designation to the investigational C. diff vaccine candidate being developed by Sanofi Pasteur. The fast-track program of the FDA is designed to facilitate the development and expedite the review of new investigational drugs and vaccines that are intended to treat or prevent serious or life-threatening conditions and demonstrate the potential to address unmet medical needs.

For more information about the Cdiffense Phase III trial, please contact the Innovative Research of West Fl., Inc. study coordination at 727-584-6368, or visit

About C. diff
Clostridium difficile (C. diff) is a potentially life-threatening, spore-forming bacterium that causes intestinal disease. According to the Centers for Disease Control and Prevention (CDC), approximately 500,000 Americans are infected with C. diff,[ii] and at least 14,000 fatalities are attributed to C. diff each year.[iii] The risk of C. diff increases with age, antibiotic treatment and time spent in hospitals or nursing homes, where multiple cases can lead to outbreaks.1 A main source of C. diff is infected patients who release spores into the environment that can then infect other people. When antibiotics disrupt the gut's normal flora and a person has ingested C. diff spores, the C. diff bacteria multiply and release potent toxins that can damage a person's intestinal lining and cause C. diff disease.[iv]

About the Innovative Research of West Fl., Inc.
Dr.Miguel Trevino MD, is a Board Certified physician specializing in Internal Medicine. He has been practicing with Innovative Research of West Fl., Inc. for 13years. Dr. Trevino, MD earned his degree from Autonomous University of Guadalajara and was trained at Albert Einstein College of Medicine in New York.

The clinical trial facility is located at 1573 S. Fort Harrison Ave. Clearwater, Fl.
For more information, please call 727-584-6368 or email

Here is the full link to the Sanofi Pasteur release:

Update: July 15, 2013

Dr. Trevino and Dr. Light welcomes Dr. Benjamin DeVries! Dr. DeVries graduated with honors from the University of Northern Iowa with a bachelor's degree in biomedicine in 2004. He then went on to receive his medical school training at the founding osteopathic medical school, A.T. Still University – Kirksville College of Osteopathic Medicine, established in 1892. See full bio >

Accepting New Patients Flyer

Update: June 4, 2013

We had a very wonderful celebration on May 10th for the wedding of Tracey Osborn and Kenneth Sim. Tracey looked absolutely beautiful and her new husband Kenneth, most handsome.

Tracey and Kenneth

The groom and groomsmen, and many of the celebrants were in authentic Scottish dress. The beautiful outdoor wedding was accented by a marching Pipe and Drum band. It was most moving. Drinks and hor'derves followed the wedding and then off to the reception for an outstanding meal, and music. We wish Tracey and Kenny our best for a long life together.

Update: May 16, 2013

Contgratulations to Tracey, our research director, who tied the knot on May 10th, 2013.

Update: April 18, 2013

Tracey Osborn, our research director, will be tying the knot May 10th 2013. We wish her and Kenny many years of happy life together.